Articles Tagged: endocannabinoid system

Holistic Biochemistry of Cannabinoids, by Dr Robert Melamede

January 20th, 2014 | By

I always had my suspicions that cannabis was a super plant, but never in my wildest dreams did I think that it could be responsible for regulating most of the body’s essential processes.  Over to Dr Bob:

“Endocannabinoids are the oil of life. And what they do is minimise. It’s friction we’re talking about. Biochemical friction essentially and what we’d like to do is minimise the consequences, essentially, we don’t want ourselves wearing out. So we need to oil ourselves appropriately, and our bodies try to do that, but there is a direction to our imbalance because even though we’re all unique and we’re all different, we all share a certain characteristic. We’re all getting older and that age is attributable to the accumulated damages that are occurring from that friction and we’ll elaborate on that a little more because as was pointed out by Dr Mephlam, these things have constructive roles as well, they are part of signalling mechanisms.

So free radicals act as chemical messengers they allow us to realise there is an imbalance, and when I say us, I mean at a chemical level between ourselves, between our organs and between us as individuals, formations in our societies, how we fix things.

But certainly on a chemical level, free radicals tell us that something is wrong, lets try to fix it. But alternatively they say something’s wrong, lets kill it, because we don’t want, for example, genetically damaged cells in us. If we can’t fix those genetically damaged cells, then we have mechanisms to do that – dna repair mechanisms – then we get rid of those cells because these are the cells that go on to become cancer.

Is marijuana the ultimate holistic medicine if it is coordinating and balancing all of these different organised entities within our body. Or is it the devil’s weed as others would have us believe?

So we are seeing it working on a sub cellular level. We see that leading up to consciousness demean by transcending scales and how its effect on consciousness has an impact on society. This is why cannabinoids have such a unique evolutionary role because they are transcending like this. So cannabinoids regulate cardiovascular health and this is all work sponsored by the NIH and  researchers all around the world. This is coming out of peer reviewed journals.  I don’t talk about my research as since I became chairman of the biology department. That’s when I shifted to cannabinoid research and it goes very very slowly when you have to waste all your time being chairman.

So cannabinoids regulate cardiovascular health and what you see here is when you have a heart attack blocking oxygen and eventually the oxygen re flows and you have a ischemia reperfusion that generates injury. That injury is free radical associated. Here what you see is that you reduce the cell death in your heart through the endocannabinoid system, so presumably exocannabinoids of various forms will have similar effects.

..Dealing with the heart, with arrhythmia and cell death, and in both cases, the cannabinoids prevent cell death and prevent arrhythmia which are fundamental problems when you have cardiovascular disease.

..It’s regulating the digestion system, so we see that the pharmacological modulation of the endocannabinoid system can provide new therapeutics for a number of diseases. Things like gastro intestinal disease, paralytic ileus, chrons disease, irritable bowel syndrome and a whole variety of digestive system related illnesses where people who are using cannabinoids know it works. This is the foundation for it. It’s this balancing act again of trying to restore biochemical health, essentially.

Cannabinoids have a profound effect on the nervous system. The key component here of this is even if these studies aren’t as positive as many expect them to be, that we are only just beginning to appreciate the huge therapeutic potential of this family of compounds is clear.

For multiple sclerosis, for pain, for spasticity, for a whole variety of neurologically related imbalances, the endocannabinoid system is how your body is trying to fix you, and if you’re not being fixed, that means you need more, so the ideal medicine is often not the little purple pill that you see on TV or any of the variety of things. In my mind, the first choice medicine should be cannabinoids when there is an indication for it because they are mimicking what your body is doing.”

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